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PLOS ONE: Effects of MDMA Injections on the Behavior of Socially-Housed Long-Tailed Macaques (Macaca fascicularis)

3,4-methylenedioxy-N-methyl amphetamine (MDMA) is one of the few known molecules to increase human and rodent prosocial behaviors. However, this effect has never been assessed on the social behavior of non-human primates. In our study, we subcutaneously injected three different doses of MDMA (1.0, 1.5 or 2.0mg/kg) to a group of three, socially housed, young male long-tailed macaques. More than 200 hours of behavioral data were recorded, during 68 behavioral sessions, by an automatic color-based video device that tracked the 3D positions of each animal and of a toy. This data was then categorized into 5 exclusive behaviors (resting, locomotion, foraging, social contact and object play). In addition, received and given social grooming was manually scored. Results show several significant dose-dependent behavioral effects. At 1.5mg/kg only, MDMA induces a significant increase in social grooming behavior, thus confirming the prosocial effect of MDMA in macaques. Additionally, at 1.5 and 2.0 mg/kg MDMA injection substantially decreases foraging behavior, which is consistent with the known anorexigenic effect of this compound. Furthermore, at 2.0 mg/kg MDMA injection induces an increase in locomotor behavior, which is also in accordance with its known stimulant property. Interestingly, MDMA injected at 1.0mg/kg increases the rate of object play, which might be interpreted as a decrease of the inhibition to manipulate a unique object in presence of others, or, as an increase of the intrinsic motivation to manipulate this object. Together, our results support the effectiveness of MDMA to study the complex neurobiology of primates’ social behaviors.

Quelle: PLOS ONE: Effects of MDMA Injections on the Behavior of Socially-Housed Long-Tailed Macaques (Macaca fascicularis)

Psychedelics and Systems Change | Charles Eisenstein

Many arguments for the legalization of cannabis and psychedelics draw on their relative harmlessness. […] In fact, the prohibitionists are correct. The legalization of cannabis, LSD, MDMA, psilocybin mushrooms, ayahuasca, and the other psychedelics would indeed mean the end of society as we know it. The threat that conservative political forces have identified is real.

Quelle: Psychedelics and Systems Change | Charles Eisenstein

Bicycle Day: LSD users share their experiences of a drug that can have life-changing effects

„My name is Charlie and I take drugs. Not many, and not often, but I don’t feel ashamed to admit that I do: quite the opposite in fact. You see today is the anniversary of the very first deliberate LSD trip, taken by Swiss scientist Albert Hofmann in 1943, and, in honour of this, it is also Psychedelic Pride.“

Quelle: Bicycle Day: LSD users share their experiences of a drug that can have life-changing effects

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